Ongoing Projects

Current Projects and Partnerships at the Hai Group

Enzymology and biocatalysis of PLP-dependent enzymes

We focus on discovering and understanding new PLP-dependent enzymes from natural product biosynthetic pathways and developing them into biocatalysts for non-canonical amino acid biosynthesis.

Biosynthesis of bioactive alkaloids

We are interested in elucidating the biosynthesis of alkaloid natural products and developing synthetic biology platform to build artificial biosynthetic pathways to access bioactive and structurally complex alkaloid. We aim to expand the chemical diversity and ultimately build unnatural bioactive alkaloids as therapeutic agents.

Biosynthesis bioactive macrocyclic peptides & amino acid polymer

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