Publications

At UCSB:

24. Hai Y, Chen M, Huang A, Tang Y. (2020) Biosynthesis of mycotoxin fusaric acid and application of a PLP-dependent enzyme for chemoenzymatic synthesis of substituted L-pipecolic acids. ChemRxiv LINK

Prior to UCSB:

23. Hai Y, Jenner M, Tang Y. (2020) Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetase. Chem. Sci. Accepted. LINK

22. Hai Y, Huang A, Tang Y. (2020) Biosynthesis of amino acid-derived a-pyrones by an NRPS-NRPKS hybrid megasynthetase in fungi. J. Nat. Prod. 83, 593-600. LINK

21. Yee DA, Kakule T, Cheng W, Chen M, Chong C, Hai Y, Hang L, Hung Y, Liu N, Ohashi M, Okorafor I, Song Y, Tang M-C, Zhang Z, Tang Y. (2020) Genome mining of alkaloidal terpenoids from a hybrid terpene and nonribosomal peptide biosynthetic pathway. J. Am. Chem. Soc. 142, 710-714. LINK

20. Hai Y, Jenner M, Tang Y. (2019) Complete stereoinversion of L-tryptophan by a fungal single-module nonribosomal peptide synthetase. J. Am. Chem. Soc. 141, 8198-8206. LINK

19. Cai Y, Hai Y, Ohashi M, Jamieson CS, Garcia-Borras M, Houk KN, Zhou J, Tang Y. (2019) Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat. Chem. 11, 812-820. LINK

18. Hai Y, Huang A, Tang Y. (2019) Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi. Proc. Natl. Acad. Sci. USA 116, 10348-10353. LINK

17. Hai Y and Tang Y. (2018) Biosynthesis of long-chain N-acyl amide by a truncated polyketide synthase-nonribosomal peptide synthetase hybrid megasynthase in fungi. J. Am. Chem. Soc.140, 1271-1274. LINK

16. Ohashi M, Liu F, Hai Y, Chen M, Tang MC, Yang Z, Sato M, Watanabe K, Houk KN, Tang Y. (2017) SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. Nature 549, 502-506. LINK

15. Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher Iii FJ, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R. (2017) ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat. Cell Biol. 19, 962-973. LINK

14. Kasznel AJ, Zhang Y, Hai Y, Chenoweth DM. (2017) Structural basis of for aza-glycine stabilization of collagen. J. Am. Chem. Soc.139, 9427-9430. LINK

13. Hai Y, Shinsky SA, Porter NJ, Christianson DW. (2017) Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat. Commun.8, 15368. LINK

12. Gao SS, Garcia-Borràs M, Barber JS, Hai Y, Duan A, Garg NK, Houk KN, Tang Y. (2017) Enzyme-catalyzed intramolecular enantioselective hydroalkoxylation. J. Am. Chem. Soc. 139, 3639-3642. LINK

11. Hai Y. and Christianson DW. (2016) Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat. Chem. Biol. 12, 741-747. Highlighted by Chem. & Eng. News. “Biological structures of the year” LINK

10. Hai Y. and Christianson DW. (2016) Crystal structures of Leishmania mexicana arginase complexed with α,α-disubstituted boronic amino acid inhibitors. Acta Cryst. F72, 300-306. LINK

9. Hai Y, Kerkhoven EJ, Barrett MP, Christianson DW. (2015) Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster. Biochemistry 54, 458-471. LINK

8. Hai Y, Edwards JE, Van Zandt MC, Hoffmann KF, Christianson DW. (2014) Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis. Biochemistry 53, 4671-4684. LINK

7. Hai Y, Dugery RJ, Healy D, Christianson DW. (2013) Formiminoglutamase from Trypanosoma Cruzi is an arginase-like manganese metalloenzyme. Biochemistry 52, 9294-9309. LINK

6. D’Antonio EL, Ullman B, Roberts SC, Dixit UG, Wilson ME, Hai Y, Christianson DW. (2013) Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Arch. Biochem. Biophys. 535, 163-176. LINK

5. D’Antonio EL, Hai Y, Christianson DW. (2012) Structure and function of non-native metal clusters in human arginase I. Biochemistry 51, 8399-8409. LINK

4. Chen JJ, Jing J, Chang H, Rong Y, Hai Y, Tang J, Zhang JL, Xu P. (2013) A sensitive and quantitative autolysosome probe for detecting autophagic activity in live and prestained fixed cells. Autophagy 9, 894-904. LINK

3. Jing J, Chen JJ, Hai Y, Zhan J, Xu P, Zhang, J.-L. (2012) Rational design of ZnSalen as a single and two photon activatable fluorophore in living cells. Chem. Sci. 3, 3315-3320. LINK

2. Cai YB, Zhan J, Hai Y, Zhang JL. (2012) Molecular assembly directed by metal–aromatic interactions: control of the aggregation and photophysical properties of Zn–Salen complexes by aromatic mercuration. Chem. Eur. J. 18, 4242-4249. LINK

1. Hai Y, Chen JJ, Zhao P, Lv H, Yu Y, Xu P, Zhang JL. (2011) Luminescent zinc salen complexes as single and two-photon fluorescence subcellular imaging probes.Chem. Commun. 47, 2435-2437. LINK

PATENT APPLICATIONS

Hai Y. and Tang Y. “Methods for producing D-tryptophan and substituted D-tryptophans”, UC Provision 2020-148-1.

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